Serum amyloid A: An acute-phase protein involved in tumour pathogenesis
Top Cited Papers
- 23 August 2008
- journal article
- review article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 66 (1) , 9-26
- https://doi.org/10.1007/s00018-008-8321-x
Abstract
The synthesis of acute-phase protein serum amyloid A (SAA) is largely regulated by inflammation- associated cytokines and a high concentration of circulating SAA may represent an ideal marker for acute and chronic inflammatory diseases. However, SAA is also synthesized in extrahepatic tissues, e.g. human carcinoma metastases and cancer cell lines. An increasing body of in vitro data supports the concept of involvement of SAA in carcinogenesis and neoplastic diseases. Accumulating evidence suggests that SAA might be included in a group of biomarkers to detect a pattern of physiological events that reflect the growth of malignancy and host response. This review is meant to provide a broad overview of the many ways that SAA could contribute to tumour development, and accelerate tumour progression and metastasis, and to gain a better understanding of this acute-phase reactant as a possible link between chronic inflammation and neoplasia.Keywords
This publication has 96 references indexed in Scilit:
- Induction of matrix metalloproteinase 1 gene expression is regulated by inflammation-responsive transcription factor SAF-1 in osteoarthritisArthritis & Rheumatism, 2003
- Inflammation and cancerNature, 2002
- Mutations of Serine 236−237 and Tyrosine 302 Residues in the Human Lipoxin A4 Receptor Intracellular Domains Result in Sustained SignalingBiochemistry, 2000
- Expression and Regulation of Constitutive and Acute Phase Serum Amyloid A mRNAs in Hepatic and Non‐Hepatic Cell LinesScandinavian Journal of Immunology, 1996
- Characterization of an isoelectric focusing variant of SAA1 (ASP-72) in a family of Turkish originBiochemical and Biophysical Research Communications, 1991
- Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1991
- Role of interleukin-6 in regulating synthesis of C-reactive protein and serum amyloid A in human hepatoma cell linesBiochemical and Biophysical Research Communications, 1988
- The effect of interleukin-1, interleukin-6 and its interrelationship on the synthesis of serum amyloid A and C-reactive protein in primary cultures of adult human hepatocytesBiochemical and Biophysical Research Communications, 1988
- Transformation of Amyloid Precursor SAA to Protein AA and Incorporation in Amyloid Fibrils in VivoScandinavian Journal of Immunology, 1985
- SErum Amyloid a Protein in Amyloidosis, Rheumatic, and Neoplastic DiseasesArthritis & Rheumatism, 1979