DISSOCIATION OF β-ADRENOCEPTOR-INDUCED EFFECTS ON AMYLASE SECRETION AND CYCLIC ADENOSINE 3′,5′-MONOPHOSPHATE ACCUMULATION

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Abstract
1 By using a multi-channel microperifusion system the effects of noradrenaline, the β1-adrenoceptor agonist prenalterol, and the β2-selective agonist terbutaline were studied on amylase release and cyclic adenosine 3′,5′-monophosphate (cyclic AMP) content in rat parotid and guinea-pig submandibular glands. 2 Noradrenaline caused significant amylase discharge and cyclic AMP accumulation. 3 Prenalterol was as effective as noradrenaline in causing amylase release but did not significantly affect the cyclic AMP content. 4 Terbutaline stimulated cyclic AMP accumulation, but had little effect on amylase secretion. 5 The present study reveals that there is a dissociation of the β-adrenoceptor-induced amylase release and cyclic AMP formation, and that this dissociation may be due to different β-adrenoceptor subtypes.