Lithiation of Uracilnucleosides and its Application to the Synthesis of a New Class of Anti-HIV-1 Acyclonucleosides
- 1 January 1991
- journal article
- oral communications
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (1-3) , 397-400
- https://doi.org/10.1080/07328319108046487
Abstract
A highly general and regioselective modification of the base moiety of uracilnucleosides can be accomplished based on lithiation chemistry. An application of this approach to the synthesis of various acyclouridine derivatives, in which both C-5 and C-6 positions were substituted, was carried out to improve the HIV-1 specific inhibitory activity of a new lead compound, l-[(2-hydroxyethoxy)methyl]-6-phenylthiothymine (HEPT).Keywords
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