Endothelial Monocyte Antigens Are Coded for by Loci Centromeric of HLA‐B

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Abstract
900 pregnancy sera were screened for monocyte antibodies. 23 sera (2.6%) were found to be reactive with monocytes in an allotypic pattern distinct from blood group ABO, HLA‐A,B,C, DR and DQ specificities. Because of strong reactions and high reproducibility, 4 sera with pure endothelial monocyte (EM) reactivity and 2 sera also positive with B lymphocytes of certain donors were selected for population and family studies. The frequency of positive reactions in a panel of 26 random donors obtaied with the pure EM sera was 13,8,8 and 13% with clearly distinct patterns. Analysis of the tentatively designated EM antigens 1.1, 1.2, 2.1, and 2.2 in 7 families revealed definite segregation with HLA. By means of two crossing‐over events within the HLA region the two hypothetical EM loci were localized centromeric of HLA‐A and one of both loci centromeric of HLA‐B.