Effect of ethosuximide on rest tremor in the MPTP monkey model
- 1 January 1992
- journal article
- research article
- Published by Wiley in Movement Disorders
- Vol. 7 (2) , 137-141
- https://doi.org/10.1002/mds.870070207
Abstract
Based on the hypothesis that low‐threshold calcium conductance in the thalamus might be involved in the pathophysiology of parkinsonian tremor, ethosuximide was given chronically to a monkey previously treated with MPTP and displaying exceptionally a typical rest tremor. After 5 days of daily treatment, the tremor was reduced by 60%. Diltiazem and verapamil which act on different calcium channels had no such effect. Ethosuximide also potentiated the antitremor effect of the dopamine D2 agonist LY‐171555.Keywords
This publication has 17 references indexed in Scilit:
- Effect of LY 171555 and CY 208‐243 on tremor suppression in the MPTP monkey model of parkinsonismMovement Disorders, 1992
- The MPTP model: versatile contributions to the treatment of idiopathic Parkinson's diseaseJournal of the Neurological Sciences, 1990
- Characterization of ethosuximide reduction of low‐threshold calcium current in thalamic neuronsAnnals of Neurology, 1989
- Monkeys with unilateral ventromedial tegmental lesions of the brain stem: Models for parkinson's disease and lesch-nyhan syndromeProgress in Neuro-Psychopharmacology and Biological Psychiatry, 1989
- Chronic treatment withl-DOPA, but not bromocriptine induces dyskinesia in MPTP-parkinsonian monkeys. Correlation with [3H]spiperone bindingBrain Research, 1986
- Symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in an old java monkey [Macaca cynamolgus fascicularis (Raffles)]Brain Research Bulletin, 1986
- Effects of interruption of the nigrostriatal pathway and of dopaminergic agents on the spontaneous activity of globus pallidus neurons in the awake monkeyBrain Research, 1979
- Ethosuximide in the treatment of absence (petit mal) seizuresNeurology, 1975
- The rubro-olivo-cerebello-rubral loop and postural tremor in the monkeyJournal of the Neurological Sciences, 1970
- STRIATAL AMINES, EXPERIMENTAL TREMOR AND THE EFFECT OF HARMALINE IN THE MONKEYBrain, 1966