Highly Selective Room-Temperature Copper-Catalyzed C−N Coupling Reactions
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- 17 June 2006
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 128 (27) , 8742-8743
- https://doi.org/10.1021/ja063063b
Abstract
Through the use of cyclic β-diketones as supporting ligands, the copper-catalyzed coupling of aryl iodides with aliphatic amines occurs at room temperature in as little as 1 h. These high reaction rates allow for the coupling of a wide range of aryl and heteroaryl iodides at room temperature. This method is highly tolerant of a number of reactive functional groups, including −Br and aromatic −NH2 as well as phenolic and aliphatic −OH. The high selectivity of the CuI−β-diketone catalyst for aliphatic amines represents a useful complement to the palladium-based methods.Keywords
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