INHIBITION OF THE PLASMA CHOLINESTERASE VARIANTS BY PROPRANOLOL

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Abstract
The inhibitory effect of( ±)propranolol 1.69 × l0−4−l.69 × 10−7 mol litre−1 on normal and atypical plasma cholinesterase variants was investigated. The atypical enzyme is less sensitive to inhibition by (±) propranolol or either of its enanticasiorphs than the usual enzyme. Propranolol 8.45 × 10−6 mol litre−1 was used as differential inhibitor of 643 plasma samples from individuals of known genotype. Although the measurement of propranolol inhibition alone is not always unambiguous for assigning a definite genotype to a given individual, the correlation of propranolol inhibition with fluoride inhibition gives clear differentiation of the E1uE1u and E1, as well as other phenotypes.