EFFECTS OF CAFFEINE ON DNA REPAIR OF UV‐IRRADIATED DICTYOSTELIUM DISCOIDEUM
- 2 January 1981
- journal article
- research article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 33 (1) , 79-83
- https://doi.org/10.1111/j.1751-1097.1981.tb04300.x
Abstract
Abstract— Caffeine enhances the UV‐killing of amoeboid cells of NC‐4, but UV‐irradiated γs‐13 is insensitive to caffeine. UV‐irradiated NC‐4 becomes insensitive to the effect of caffeine during a postirradiation incubation in buffer for about 90 min, but γs‐13 remains unchanged in the sensitivity to caffeine throughout the incubation for 180 min. Amoeboid cells of γs‐13 can remove pyrimidine dimers as well as NC‐4 even in the presence of caffeine. Caffeine inhibits rejoining of strand‐breaks of DNA in UV‐irradiated NC‐4, but the rejoining in γs‐13 is insensitive to caffeine.This publication has 27 references indexed in Scilit:
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