Liquid Chromatographic Resolution of Enantiomeric Dipeptides on the Chiral Stationary Phase Derived from (S)-1-(6,7-Dimethyl-1-naphthyl)isobutylamine
- 1 May 1988
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 11 (6) , 1249-1259
- https://doi.org/10.1080/01483918808067170
Abstract
Liquid chromatographic resolution of fifteen enantiomeric dipeptide methyl esters as their N-3,5-dinitrobenzoyl derivatives was investigated on the chiral stationary phase (CSP) derived from (S)-1-(6,7-dimethyl-1-naphthyl)isobutylamine. The four stereoisomers present in each dipeptide derivative were observed to be separated quite well with the (R,R) isomer being eluted first. The separation factors for two enantiomeric pairs such as (R,R)/(S,S) and (R,S)/(S,R) and the elution orders are explained by two competing “opposite-sense” chiral recognition mechanisms.This publication has 14 references indexed in Scilit:
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