Clinical application of18F-FUdR in glioma patients ? PET study of nucleic acid metabolism
- 1 January 1995
- journal article
- clinical trial
- Published by Springer Nature in Journal of Neuro-Oncology
- Vol. 23 (1) , 53-61
- https://doi.org/10.1007/bf01058459
Abstract
Positron emission tomography was used to investigate the metabolism of nucleic acids by18F-fluoro-2′-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 ± 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 ± 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.Keywords
This publication has 41 references indexed in Scilit:
- Tumor diagnosis by pet: potential of seven tracers examined in five experimental tumors including an artificial metastasis modelInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1992
- Metabolic fates of 2′-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasmaInternational Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1991
- The accumulation of11C-methionine in cerebral glioma patients studied with PETActa Neurochirurgica, 1990
- Automated synthesis of 5-[18F]fluoro-2′-deoxyuridineInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1987
- Positron Emission Tomography Using [18F] Fluorodeoxyglucose in Brain Tumors A Powerful Diagnostic and Prognostic ToolInvestigative Radiology, 1987
- Stereotaxic biopsy and positron emission tomography correlation of cerebral gliomasSurgical Neurology, 1987
- Prediction of survival in glioma patients by means of positron emission tomographyJournal of Neurosurgery, 1985
- Positron Emission Tomographic Evaluations in the Diagnosis and Therapy of Multifocal GlioblastomaPediatric Neurosurgery, 1985
- In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomasAnnals of Neurology, 1983
- In vivo measurements of regional cerebral blood flow and blood volume in patients with brain tumours using positron emission tomographyActa Neurochirurgica, 1983