Comparison of the pharmacokinetics of digoxin and dihydrodigoxin in cats in single-dose studies

Publisher Website
Google Scholar
Abstract
Pharmacokinetics of 3H-dihydrodigoxin and 3H-digoxin after single intravenous and intraduodenal administration in cats are compared. Data could be described by an open two compartment body model. The β half-life in plasma of dihydrodigoxin after initial rapid distribution is 4.6 h compared to 10.4 h after digoxin administration. The volume of tissue distribution of dihydrodigoxin is 7 times smaller than that of digoxin (0.31 l versus 2.05 l). The “specific uptake” of dihydrodigoxin into myocardium and some other tissues is very low. Over 5.5 h the cumulative biliary and urinary elimination of dihydrodigoxin is definitely higher (45.7% versus 14.4%). An unexpected peak in TLC plates after dihydrodigoxin administration in blood, bile and urine was identified to be the sodium salt of the opened lactone structure: dihydrodigoxin acid.

This publication has 22 references indexed in Scilit: