Uremic Galactorrhea: an Endocrine Profile

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Abstract
Abnormal lactation (galactorrhea) was observed in 5 female patients with renal failure. This appeared in association with amenorrhea in the terminal stage of renal failure. Lactation gradually decreased in the course of maintenance hemodialysis. Hypoestradiolemia and hyper-LH-emia found in these cases reflect ovarian dysfunction, and the results obtained with TRH and LH-RH infusion tests indicate that the patients were also suffering from hypopituitarism. All cases with lactation showed high plasma prolactin levels, with no organic abnormalities identified in their pituitary glands. We conclude that hyperprolactinemia and pituitary-gonadal dysfunction were responsible for the abnormal lactation of these patients.

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