BODY TEMPERATURE AND OXYGEN CONSUMPTION IN TRAUMATIC SHOCK AND HEMORRHAGE IN MICE

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Abstract
A fall in metabolic rate and in temperature has been demonstrated in traumatic shock in mice. Body temp. approaches room temp., and death in hypothermia can be brought about at an environmental temp. of 18-22[degree]C. An impairment in circulation, as indicated by a diminution of bleeding volume to 30% of normal, has been shown. Evidence is presented that these disturbances are a result of factors originating in the injured tissues. Available therapeutic measures have little effect upon them, but ligation of the injured tissues, even after several hours, will correct them. The fall in temp. following hemorrhage results from a diminished capacity for O2 transport. The temp. can be restored by O2 or by whole blood therapy. In tourniquet-shocked mice that have received adequate therapy the optimum temp. for survival is 25 to 29[degree]C. At these temps., the majority of mice will survive an otherwise fatal trauma if they receive 10-15% of their body wt. of isotonic NaCl. Outside this temp. range, the harmful effects of heat and cold appear; they are related to factors arising from the injured tissues and are little influenced by available therapy.

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