BIOCHEMICAL CHANGES IN THE BLOOD OF RATS AFTER REAPPLICATION OF LIMB TOURNIQUETS

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Abstract
Detns. of blood glucose, pentose, lactic and pyruvic acids, and plasma inorganic phosphate and amino acid N were made oh rats which had limb tourniquets in place for 4 hrs. followed by release and reapplication for different times. Correlation of these data with those obtained from survival studies made on rats in which tourniquets had been reapplied after a period of release, show that there are progressive changes in the blood constituents after tourniquet release which are indicative of abnormal metabolism and approaching death. The most striking changes were found in lactic acid, phosphate and plasma amino acid N. Reapplication of tourniquets for 2 or 4 hrs. prevented progressive changes in the blood constituents and death of all the rats was prevented if the tourniquets were reapplied after periods of release not greater than 6 hrs.

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