Asymmetric Synthesis XI: Stereoselective Synthesis of α-Alkyl-2-Furfurylamines Via d-Camphor Ketimine Intermediate
- 1 November 1990
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 20 (19) , 3077-3083
- https://doi.org/10.1080/00397919008051528
Abstract
(R)-α-alkyl-2-furfurylamines (7), ranging from 5–67%d.e., are obtained by asymmetric alkylation of d-camphor ketimine (3). Using 1,3-diiodopropane and dibromoxylene as alkylating reagents, diimine derivatives (6f) and (6g) are formed. However, 1,2-dibromoethane gives coupling product (6h).Keywords
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