SERUM PROTEIN-BOUND IODINE AND SERUM LIPID CHANGES IN THE THYROIDECTOMIZED, HYPOPHYSECTOMIZED, CASTRATED AND ADRENALECTOMIZED BABOON (PAPIO URSINUS)

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Abstract
SUMMARY: Thyroidectomy, hypophysectomy, pituitary stalk section and thyro-hypophysectomy cause a rapid decline in the serum protein-bound iodine (PBI) of the baboon. A low PBI level was, however, persistently maintained in serum from thyroidectomized baboons. The serum PBI of castrated baboons remained normal, whereas a significant increase was observed after adrenalectomy. The mean serum lipids and cholesterol:lipid phosphorus ratio were elevated in thyroidectomized baboons and tended to return to normal in cases of thyroid nodule regeneration. After hypophysectomy and pituitary stalk section the serum total cholesterol was higher than that of the normal adult baboon, while thyro-hypophysectomy resulted in a significant decrease of the total lipids, total cholesterol and lipid phosphorus. These low lipid concentrations in the absence of the pituitary and thyroid were maintained more consistently than in the normal thyroidectomized or hypophysectomized baboon. Castration in the baboon led to a significant rise of all lipid fractions under investigation. Hypophysectomy in the baboon caused an increased sensitivity to adrenocorticotrophic hormone and cortisone, as judged by the serum lipid response. Such an increased sensitivity seemed to be absent in the thyro-hypophysectomized baboon.