HLA Variants of Cultured Human Lymphoid Cells: Evidence for Mutational Origin and Estimation of Mutation Rate

19 August 1977

journal article
research article
Published by American Association for the Advancement of Science (AAAS) in Science

Vol. 197 (4305) , 769-771
https://doi.org/10.1126/science.70075

Abstract

Variants of a diploid lymphoid cell line that show a loss of HLA-B27 antigen occur randomly in time and independently of exposure to the alloantiserum used for their isolation. From these and previous findings of variant stability, inducibility by mutagens, and the absence of linked variation, we colclude that most HLA variants arise by mutation. The mutation rate for HLA-B27 loss is 8 x 10(-7) per cell per generation.

This publication has 14 references indexed in Scilit:

Induction of HLA mutations by chemical mutagens in human lymphoid cells
Immunogenetics, 1977
On the relationship between spontaneous mutation rates in vivo and in vitro
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
Histocompatibility gene mutation rates: H-2 and non-H-2
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1975
Chromosome-Wide Event Accompanies the Expression of Recessive Mutations in Tetraploid Cells
Science, 1975
The H-2 Major Histocompatibility Complex and the/Immune Response Region: Genetic Variation, Function, and Organization
Published by Elsevier ,1975
Alloantigenic variant selection in vitro from a mouse lymphoma — Sarcoma hybrid
Immunogenetics, 1974
Expression of New Antigens by HL-A Variants of Cultured Lymphoid Cells
The Journal of Immunology, 1974
Resistance of cultured human fibroblasts and other cells to purine and pyrimidine analogues in relation to mutagenesis detection
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1974
Antigenic Expression and Cross Reactions in HL‐A Variants of Lymphoid Cell Lines
Tissue Antigens, 1974
Aggregation of HL-A Antigens at the Lymphocyte Surface Induced by Antiserum to β ₂ -Microglobulin
Science, 1973