Immunization of Volunteers with Soluble Antigens of Adenovirus Type 1

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Abstract
Summary Vaccination with non-infectious, type-specific and group-specific soluble antigens of adenovirus type 1 induced neutralizing antibody in adult volunteers. As compared with non-immunized controls, ocular challenge of volunteers immunized with both preparations was followed by a significant reduction in throat and rectal virus shedding. There was almost complete suppression of illness in volunteers receiving type-specific antigen. It is difficult to interpret the illness pattern in the man who was given group-specific antigen. These findings suggest that soluble antigens of adenovirus type 1 may provide effective immunization in this disease.