Expression of a large family of POU-domain regulatory genes in mammalian brain development
- 6 July 1989
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 340 (6228) , 35-42
- https://doi.org/10.1038/340035a0
Abstract
A novel region referred to as the POU-domain is present in two tissue-specific transcription factors, Pit-1 and Oct-2, that activate expression of genes specifying pituitary and lymphocyte phenotypes. We report the identification of multiple new members of a large family of POU-domain genes expressed in adult brain, and document that all the known mammalian POU-domain genes, including Pit-1 and Oct-2, are expressed widely in the developing nervous system.Keywords
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