Genetic pathways to colorectal cancer.
- 15 November 1997
- journal article
- review article
- Published by Taylor & Francis in Hospital Practice
- Vol. 32 (11) , 79-96
- https://doi.org/10.1080/21548331.1997.11443598
Abstract
The first known cancer family would be described today as having hereditary nonpolyposis colorectal cancer, in which, as in familial adenomatous polyposis, the emergence of a malignancy requires a seemingly unlikely sequence of somatic mutations, superimposed on a risk-conveying inheritance. Events identified in the inherited syndromes are proving crucial in learning precisely how nonfamilial tumors developKeywords
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