INHIBITION OF PRECURSOR INCORPORATION INTO NUCLEIC ACIDS OF MAMMALIAN TISSUES BY ANTIMALARIAL AMINOQUINOLINES
Open Access
- 1 February 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 62 (2) , 159-164
- https://doi.org/10.1111/j.1476-5381.1978.tb08440.x
Abstract
1 Chloroquine, primaquine and ethidium inhibited thymidine incorporation into deoxyribonucleic acid of rat tissues when administered concurrently with the labelled precursor. 2 Chloroquine and primaquine inhibited the incorporation of uridine and adenine, but not orotate, into various ribonucleic acid fractions of liver of rats and mice. These drugs had no effect on leucine incorporation into hepatic protein in rats or mice. 3 Although chloroquine and primaquine are active against different stages in the life cycle of the malarial parasites, the two aminoquinolines exert similar effects in rodent tissues.Keywords
This publication has 28 references indexed in Scilit:
- Binding to deoxyribonucleic acid and inhibition of ribonucleic acid polymerase by analogs of chloroquineJournal of Medicinal Chemistry, 1974
- Inhibition of aminoacylation and polypeptide synthesis by chloroquine and primaquine in rat liver in vitroBiochemical Pharmacology, 1973
- Binding of antimalarial aminoquinolines to chromatin, reconstituted deoxyribonucleohistone and ribosomes from mammalian tissuesBiochemical Pharmacology, 1973
- Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. II. Independent snucleotide pools for nucleic acid synthesisJournal of Cellular Physiology, 1971
- Aminoquinoline antinialarials—Paradoxical regulation of hepatic tryptophan oxygenase and tyrosine aminotransferase by primaquineBiochemical Pharmacology, 1971
- Studies concerning the mechanism of action of antimalarial drugs—: Inhibition of the incorporation of adenosine-8-3H into nucleic acids of Plasmodium bergheiBiochemical Pharmacology, 1969
- Aminoacyl Transfer Ribonucleic Acid Synthetases from Cell-Free Extract of Plasmodium bergheiScience, 1969
- DNA biosynthesis in mitochondria: Differential inhibition of mitochondrial and nuclear DNA polymerases by the mutagenic dyes ethidium bromide and acriflavinBiochemical and Biophysical Research Communications, 1969
- Coenzyme Q. CVIII. Inhibition of coenzyme Q systems by chloroquine and other antimalarialsJournal of the American Chemical Society, 1968
- Primaquine-Induced Changes in Morphology of Exoerythrocytic Stages of MalariaScience, 1968