Palmitate-14C uptake by rat lung effect of altered gas tensions

Publisher Website
Google Scholar
Abstract
The effect of altered gas tensions on the incorporation and turnover of palmitate-l-14C in rat lung lipid was studied in vivo. Acute hypoxia decreased both the incorporation and turnover of labeled fatty acid in lung triglyceride and phospholipid. Acute hypercapnia increased the incorporation and turnover of palmitate-14C in triglyceride but had little effect on the phospholipids of lung tissue. By contrast, hyperbaric oxygenation enhanced the incorporation of labeled fatty acid into several lung phospholipids but had no effect on triglyceride. In acute hypoxia, hypercapnia, and hyperbaric oxygenation, the surface activity of material expressed from the cut surface of the lung was unaltered as measured by bubble stability. Acute alterations in the gaseous environment of the lung can result in a variety of changes in its lipid metabolism which have no immediate effects on the surface activity of lung lining material.