Modified 3-Alkyl-1,8-dibenzylxanthines as GTP-Competitive inhibitors of phosphoenolpyruvate carboxykinase
- 15 August 2003
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 13 (20) , 3607-3610
- https://doi.org/10.1016/s0960-894x(03)00722-4
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- X-ray Structures of two xanthine inhibitors bound to PEPCK and N -3 modifications of substituted 1,8-DibenzylxanthinesBioorganic & Medicinal Chemistry Letters, 2003
- Phosphoenolpyruvate Carboxykinase Overexpression Selectively Attenuates Insulin Signaling and Hepatic Insulin Sensitivity in Transgenic MiceJournal of Biological Chemistry, 2002
- QSAR studies of 8-substituted xanthines as adenosine receptor antagonistsEuropean Journal of Medicinal Chemistry, 1994
- Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus.Proceedings of the National Academy of Sciences, 1994
- Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptorsJournal of Medicinal Chemistry, 1993
- Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonistsJournal of Medicinal Chemistry, 1993
- Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigationsJournal of the American Chemical Society, 1991
- Electronegativity and bond energyJournal of the American Chemical Society, 1983
- Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblastsBiochemical Pharmacology, 1981
- Synthesis of 1-Mono- and 1,3-Di-Substituted 6-Aminouracils. Diuretic ActivityThe Journal of Organic Chemistry, 1951