X-ray Structures of two xanthine inhibitors bound to PEPCK and N -3 modifications of substituted 1,8-Dibenzylxanthines
- 22 September 2003
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 13 (21) , 3871-3874
- https://doi.org/10.1016/s0960-894x(03)00723-6
Abstract
No abstract availableKeywords
This publication has 12 references indexed in Scilit:
- Modified 3-Alkyl-1,8-dibenzylxanthines as GTP-Competitive inhibitors of phosphoenolpyruvate carboxykinaseBioorganic & Medicinal Chemistry Letters, 2003
- Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding siteJournal of Molecular Biology, 2002
- Exploiting Chemical Libraries, Structure, and Genomics in the Search for Kinase InhibitorsScience, 1998
- Synthesis and Structure-Activity Relationships of Deazaxanthines: Analogs of Potent A1- and A2-Adenosine Receptor AntagonistsJournal of Medicinal Chemistry, 1994
- Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptorsJournal of Medicinal Chemistry, 1993
- Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonistsJournal of Medicinal Chemistry, 1993
- Synthesis of 3-substituted 6-aminouracilsTetrahedron Letters, 1991
- Catalytic antibodies with acyl-transfer capabilities: mechanistic and kinetic investigationsJournal of the American Chemical Society, 1991
- A novel synthesis of xanthines: support for a new binding mode for xanthines with respect to adenosine at adenosine receptorsJournal of Medicinal Chemistry, 1990
- A model for the antagonist binding site on the adenosine A1 receptor, based on steric, electrostatic, and hydrophobic propertiesJournal of Medicinal Chemistry, 1990