A new steroidal alkylating agent with improved activity in advanced murine leukemias
- 1 August 1979
- journal article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 3 (1) , 67-70
- https://doi.org/10.1007/bf00254423
Abstract
The homo-aza-steroidal ester of [p-[bis(2-chloroethyl)amino]phenoxy] acetic acid, 3β-hydroxy 13α-amino-13,17-seco-5α-androstan-17-oic-13,17-lactam-p-bis(2-chloroethyl)aminophenoxyacetate, gave a 100% increase in lifespan over controls in the treatment of L1210 leukemia by IP administration on a days 1 and 4 treatment schedule. This ester gave a maximum activity of 383% increased lifespan over controls in the treatment of P388 leukemia by IP administration on a daily treatment schedule. Activity in advanced L1210 (41% increased lifespan) and P388 leukemias (173% increased lifespan) was maintained, indicating that this compound is the most promising of a number of congeners tested to date.Keywords
This publication has 5 references indexed in Scilit:
- New Compounds: Antitumor Activity of 3β - Hydroxy-13 α - amino -13,17 - seco - 5α- androstan -17 - oic -13,17 - lactam 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyrateJournal of Pharmaceutical Sciences, 1978
- Effects of homo-aza-steroidal ester of p-BIS(2-chloroethyl)amino phenyl acetic acid on lymphocytes stimulated with phytohemagglutinin in vitroThe Journal of Steroid Biochemistry and Molecular Biology, 1978
- ANTILEUKEMIC EFFECT OF HOMO-AZA-STEROIDAL ESTER OF [PARA-[BIS(2-CHLOROETHYL)AMINO]PHENYL]ACETIC ACID1977
- Antitumor activity of a homo-aza-steroidal ester of (p-(bis(2-chloroethyl)amino)phenyl)acetic acid (NSC-71964).1973
- Steroids. LXXXIII. Effects of some steroidal alkylating agents on experimental animal mammary tumor and leukemia systemsJournal of Medicinal Chemistry, 1969