THE RELATION OF THE ADRENAL TO BLOOD FORMATION IN THE RAT1

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Abstract
THE possibility of an endocrine relation to certain processes of hemopoiesis has been recognized for some time. The earlier clinical papers reporting peripheral hematologic alterations as an accompaniment of pituitary (Silver, 1933), thyroid (Emery, 1923), or adrenal (Rowe, 1929) hypofunctional states have been given additional credence in experiments performed in the laboratory animal (see reviews by Gordon and Charipper, 1947, and Daughaday, Williams and Daland, 1948). The evidence is also clear that adequate replacement therapy will prevent or overcome many of the hemic changes characteristic of endocrine dysfunction (Meyer, Thewlis and Rusch, 1940; Vollmer and Gordon, 1941; Vollmer, Gordon and Charipper, 1942; Crafts, 1946a, b). Impetus to further research in this field has been provided of late by the findings that adrenal cortical hormones exert an influence upon the numbers and types of white cells in the peripheral blood (Dougherty and White, 1944; White and Dougherty, 1945; Forsham, Thorn, Prunty and Hills, 1948)