EFFECT OF SEX AND GONADOTROPIC HORMONES UPON THE BLOOD PICTURE OF THE RAT

Publisher Website
Google Scholar
Abstract
Pregnant mare serum treatment greatly increased the sex difference, normally found in the erythro-cyte counts of unoperated rats, by raising the counts of the [male][male] and lowering those of [female][female]. The red cell counts of castrated [female][female] were not affected by PMS. When rats rendered anemic by hypophysectomy were treated with PMS the counts of the [male][male] returned to normal, while those of the [female][female] were unaffected. The low counts of hypophysectomized animals of both sexes were increased to normal levels by injs. of testosterone propionate; this hormone also increased slightly the counts of castrated [female][female]. Reticulocyte counts and bone marrow sections give evidence of stimulation of the bone marrow by androgens and depression by estrogens. Normal sex differences in the red cell count are probably due to some action of the sex hormones.