The distribution of urethane in animal tissues, as determined by a microdiffusion method, and the effect of urethane treatment on enzymes

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Abstract
Urethane in blood, urine or tissue extracts can be estimated in Conway units by incubation with KOH and absorption of the ethanol formed, in acid dichromate. Following injn. urethane becomes evenly distributed in all the tissues of the body. Only a small amt. is excreted in urine, the greater part being metabolized. The metabolism is slower in tumor-bearing rats than in normal rats. Of 2 patients treated with urethane, the blood of one showed a decrease in true cholinesterase while the blood pseudocholin-estcrase of the other patient decreased. Treatment of rats or mice with urethane in doses sufficient to cause inhibition of mitosis or induce cancer of the lung did not reduce the respiration or glycolysis of lung, jejunum or Walker carcinoma tissue.
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