Heterozygosity and Homozygosity for the High Oxygen Affinity Hemoglobin Tarrant or α126 (H9) ASP→ASN in two Mexican Families

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Abstract
Two Mexican families from Jalisco were studied in which 11 members were carriers of Hb Tarrant. Ten subjects were Hb Tarrant heterozygotes producing .apprx. 25% of the abnormal Hb. One 9 yr old boy was homozygous for Hb Tarrant. About 50% of his Hb was of the variant type. The heterozygotes had mild erythrocytosis; this was considerably more severe in the homozygote. The average P50 value for heterozygotic blood was 15.1 mm Hg (controls: 22.5 mm Hg) and this value decreased to 9 mm Hg in the homozygote. The clinical condition of the homozygote is compatible with a mild chronic tissue hypoxia.