Studies of Bladder Stone Disease in Thailand

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Abstract
Eighteen infants, 5–18 months of age, living in an endemic bladder stone area of Ubol Province, Thailand, were administered dl-methionine, pyridoxine·HCl, or placebo in a cross-over, multiple Latinsquare designed study. Following 6 days of treatment, 24-hr urine samples were collected and analyzed for various components. Inorganic sulfate excretion was increased following methionine administration, but not with pyridoxine. These data, plus those indicating low urea excretion by village children compared with Bangkok subjects, suggest that protein malnutrition exists in Ubol villages and may contribute to the etiology of bladder stone disease.

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