CHLAMYDIAL SERUM IgG ANTIBODIES IN PATIENTS WITH ACUTE SALPINGITIS MEASURED BY AN ENZYME‐LINKED IMMUNOSORBENT ASSAY
- 1 November 1982
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Series C: Immunology
- Vol. 90C (1-6) , 67-71
- https://doi.org/10.1111/j.1699-0463.1982.tb01419.x
Abstract
An enzyme-linked immunosorbent assay (ELISA) for the detection of serum IgG antibodies to Chlamydia trachomatis was developed. The C. trachomatis subtype LGV-2 was used as antigen. The ELISA was reproducible and its sensitivity and specificity compared well with that of the single-antigen immunofluorescence test (r = 0.83). Of the 34 patients, 29 (85%) with acute salpingitis had chlamydial serum IgG antibodies measured by the ELISA technique. The detection level in single blood donor specimens was 30%. Among the 34 patients with acute salpingitis, 16 paired serum specimens showed a 4-fold or greater rise/fall in antibody titers, and 12 of these belonged to the 19 who harbored C. trachomatis in the lower genital tract.Keywords
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