A strain of monkey malaria (Plasmodium cynomolgi) made resistant to proguanil (paludrine)

1 June 1951

journal article
research article
Published by Oxford University Press (OUP) in Transactions of the Royal Society of Tropical Medicine and Hygiene

Vol. 44 (6) , 695-701
https://doi.org/10.1016/0035-9203(51)90005-3

Abstract

Subeffective treatment of infections of monkeys by proguanil has produced strains with 1000 times the resistance to the drug present in the original strain. Such resistance is not impaired by passage through mosquitoes nor does freezing of infected blood change the reaction. Pre-erythro-cytic, endo-erythrocytic, and gametocytic stages all show this increased resistance. Such strains are readily controlled through sulphadiazine therapy.

Keywords

This publication has 14 references indexed in Scilit:

Morphological changes in Plasmodium cynomolgi following proguanil, sulphadiazine, and mepacrine therapy
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1951
Sulphadiazine-resistance in Plasmodium gallinaceum and its relation to other antimalarial compounds
Parasitology, 1950
Paludrine resistant falciparum malaria
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1949
ACQUIRED RESISTANCE TO PROGUANIL IN PLASMODIUM FALCIPARUM
The Lancet, 1949
ACQUIRED RESISTANCE TO PROGUANIL (PALUDRINE) IN PLASMODIUM VIVAX
The Lancet, 1949
RESISTANCE TO PROGUANIL (PALUDRINE) IN A MAMMALIAN MALARIA PARASITE (PLASMODIUM CYNOMOLGI)
The Lancet, 1948
Drug-resistance in Plasmodium gallinaceum, and the persistence of paludrine-resistance after mosquito transmission
Parasitology, 1948
TISSUE FORMS OF A MALARIA PARASITE PLASMODIUM CYNOMOLGI
The Lancet, 1948
Acquired Resistance (Twofold) to Quinine in Plasmodium gallinaceum
Nature, 1947
Acquired Resistance to Paludrine in Plasmodium Gallinaceum
Nature, 1947