Tumor‐associated antigens of chemically‐induced murine tumors; the emergence of MuLV and fetal antigens after serial passage in culture

Publisher Website
Google Scholar
Abstract
Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically‐induced colon carcinomas, 3 chemically‐induced sarcomas, 1 murine leukemia virus (MuLV) induced leukemia, 1 irradiation Induced leukemia, 1 spontaneous melanoma and 1 spontaneous sarcoma). We were able to detect and distinguish between at least five separate antigenic specificities on these tumors. Unique tumor‐associated antigens were found on 3 of the tumors, MuLV related antigens on 8 tumors, fetal antigens on 7 tumors and two distinct common antigens on 7 tumors (common antigen 1 (CA‐1) on 5 tumors and common antigen 2 (CA‐2) on 2 tumors). Neither of the common antigens was found to be sarcoma, carcinoma or tissue‐type specific. A number of tumors which did not originally express either MuLV or fetal antigens in primary cultures expressed these antigens after several serial passages in vitro.

This publication has 30 references indexed in Scilit: