STRUCTURE AND DEVELOPMENT OF VIRUSES OF THE PSITTACOSIS-LYMPHOGRANULOMA GROUP OBSERVED IN THE ELECTRON MICROSCOPE

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Abstract
In thin sections of lungs of mice infected with the Maeda strain, a member of the psittacosis-lymphogranuloma group isolated from a cow, viral forms were classified into elementary bodies, intermediate forms, large forms, and incomplete forms. In addition to these viral forms, the matrix which was considered to be a pre-existing component of viral forms was described. Inclusion bodies, which were intracellular colonies of these viral structures, could be divided into four types according to the prevailing kind of viral structures contained. In chorio-allantoic membranes of embryonated eggs inoculated with Cal 10 strain of meningopneumonitis virus, the development of viral forms was followed according to the lapse of time after inoculation. The matrix was a viral structure which appeared first in the cytoplasm of infected cells. In the next stage, incomplete limiting membranes developed in the periphery of the matrix and enclosed portions of the matrix progressively, thus giving rise to the incomplete forms. Then large forms developed by the completion of limiting membranes. Viral forms in these stages of development were segmented by the constriction of limiting membranes. The large forms reduced in size gradually to transform into intermediate forms, from which elementary bodies, the virus at its terminal stage of development, developed.

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