Effects of Localized Hypoxia on the Electrophysiological Activity of Cochlea of the Guinea Pig

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Abstract
Solutions of glucose oxidase and its substrate were injected into the scalae to render the organ of Corti hypoxic without affecting oxygen tension in the stria vascularis. It was thus possible to depress action potentials and microphonics, leaving the dc potential largely unaffected, to suppress entirely the action potential of a tone pip of 12 000 cps without similarly suppressing that of 1000 cps, and to diminish the microphonics in one turn without detecting the decrease with an electrode placed in another turn or against the round window. These results were taken to show that the dc potential originates in the stria vascularis, that a tone of 12 000 cps elicits an action potential only in the first cochlear turn, and that a unipolar electrode records only from a limited distance.

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