Formation of transmembrane tubules by spontaneous polymerization of the hydrophilic complement protein C9
- 1 August 1982
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 298 (5874) , 534-538
- https://doi.org/10.1038/298534a0
Abstract
The 9th component of complement (C9) can undergo circular polymerization in the fluid phase and on lipid membranes. The concomitant hydrophilic-amphiphilic transition is the result of a conformational reorganization of C9 and allows insertion of poly C9 into membranes in the form of a transmembrane protein channel. The ultrastructure of poly C9 resembles that of membrane lesions caused by complement.Keywords
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