MOLECULAR ANALYSIS OF THE MEMBRANE ATTACK MECHANISM OF COMPLEMENT
Open Access
- 1 March 1972
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 135 (3) , 549-566
- https://doi.org/10.1084/jem.135.3.549
Abstract
The molecular arrangement of the membrane attack mechanism of complement was explored. The molar ratios of the components within the C5-9 assembly on the target cell surface were determined using human complement proteins in highly purified and radiolabeled form. With the aid of monospecific complement antisera it was possible to probe the spatial relationships between the components of the assembly.Keywords
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