Control and function of lysyl‐tRNA synthetases: diversity and co‐ordination
- 27 October 1993
- journal article
- review article
- Published by Wiley in Molecular Microbiology
- Vol. 10 (2) , 225-231
- https://doi.org/10.1111/j.1365-2958.1993.tb01948.x
Abstract
Lysyl-tRNA synthetases are synthesized from two distinct genes in Escherichia coli, lysS (constitutively) and lysU (inducibly); however, the physiological significance and the differential control mechanism of these two genes have been a long-standing puzzle. Recent studies have successfully uncovered a significant control mechanism of lysU expression, which involves the leucine-responsive regulatory protein (Lrp) and a translational enhancer element called 'downstream box'. Moreover, it is likely that there is a mechanism underlying co-ordinate expression of lysU with other genes outside the leucine-Lrp regulon under harsh conditions such as low pH and anaerobiosis. A possible mechanism of lysyl-tRNA synthetase expression and function is reviewed.Keywords
This publication has 57 references indexed in Scilit:
- Lrp, a Global Regulatory Protein of Escherichia coli, Binds Co-operatively to Multiple Sites and Activates Transcription of ilvIHJournal of Molecular Biology, 1993
- Differential regulation of two genes encoding lysyl-tRNA synthetases in Escherichia coli: lysU-constitutive mutations compensate for a lysS null mutationMolecular Microbiology, 1992
- Escherichia coli leucine‐responsive regulatory protein (Lrp) controls lysyl‐tRNA synthetase expressionFEBS Letters, 1992
- Sequence requirements for efficient translational frameshifting in the Escherichia coli dnaX gene and the role of an unstable interaction between tRNA(Lys) and an AAG lysine codon.Genes & Development, 1992
- Aminoacyl‐tRNA synthetases and DNA replication Molecular mimicry between RNAII and tRNALysFEBS Letters, 1991
- Recent advances in peptide chain terminationMolecular Microbiology, 1990
- On the mechanism of ribosomal frameshifting at hungry codonsJournal of Molecular Biology, 1988
- Aminoacylation of Synthetic DNAs Corresponding to Escherichia coli Phenylalanine and Lysine tRNAsScience, 1988
- Multiple mechanisms for initiation of ColE1 DNA replication: DNA synthesis in the presence and absence of ribonuclease HCell, 1987
- Positive regulatory gene for temperature-controlled proteins in Escherichia coliBiochemical and Biophysical Research Communications, 1981