Induction of Brain D(—)-β-Hydroxybutyrate Dehydrogenase Activity by Fasting

Abstract
D(m)-β-hydroxybutyrate dehydrogenase activity is very low in normal adult rat brain; but during fasting it increases severalfold in parallel with the ketosis. The increase may represent part of a mechanism by which the brain adapts to changing patterns of substrate supply during starvation.