Experimental use of cultured cerebellar cortical tissue to inhibit the collagenous scar following spinal cord transection

Publisher Website
Google Scholar
Abstract
✓ Two types of barrier to axonal regeneration in the spinal cord were found in experimental spinal cord transection in dogs. One was an astroglial scar formed within the spinal cord, and the other a collagenous scar in the gap between proximal and distal stumps. Autogeneous cultured cerebellar cortical slices transplanted into the space produced by cord transection in adult dogs inhibited collagenous scar formation and converted the gap into a spongy structure. The astroglial scar within the spinal cord remained unchanged. Conversely, transplantation of noncultured cortical slices as a control study enhanced formation of the collagenous scar.