Augmentation of chemically induced pancreatic and bronchial cancers by epidermal growth factor.
Open Access
- 1 January 1987
- Vol. 28 (Suppl) , 249-251
- https://doi.org/10.1136/gut.28.suppl.249
Abstract
The incidence of Syrian golden hamsters with pancreatic cancer induced by subcutaneous injections of N-nitroso-bis(2-oxopropyl)amine for 19 weeks (each 10 mg/kg) increased from 44% to 75% (p=0.016) when epidermal growth factor was also administered from week 5 through week 8 (5 mug energy three days for injections). Epidermal growth factor increased pancreatic weight and body weight. The incidence of animals with bronchial cancer doubled. Epidermal growth factor could be a cocarcinogen as a result of its mitogenic activity.Keywords
This publication has 27 references indexed in Scilit:
- Variations in mortality by weight among 750,000 men and womenPublished by Elsevier ,2004
- Genes encoding pancreatic polypeptide and neuropeptide Y are on human chromosomes 17 and 7.Journal of Clinical Investigation, 1986
- The Action of Oncogenes in the Cytoplasm and NucleusScience, 1985
- Recycling of epidermal growth factor in a human pancreatic carcinoma cell line.Proceedings of the National Academy of Sciences, 1985
- Autocrine growth factors and cancerNature, 1985
- Stimulation by somatostatin of dephosphorylation of membrane proteins in pancreatic cancer MIA PaCa‐2 cell lineFEBS Letters, 1985
- Mouse prepro-epidermal growth factor synthesis by the kidney and other tissuesNature, 1985
- Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequencesNature, 1984
- Adaptation to jejunoileal bypass promotes experimental colorectal carcinogenesisBritish Journal of Surgery, 1984
- Epidermal growth factor enhancement of skin tumor induction in miceCellular and Molecular Life Sciences, 1976