Hydrolysis of Succinylmonocholine by a Liver Esterase.

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Abstract
The livers of rat and of other animals, including man, contain an esterase, distinct from known cholinesterases, which hydrolyses succinylmonocholine. The enzyme is located in the mitochondria and can be extracted from a liver acetone-powder with dilute ammonium hydroxide. It has been partially purified by ammonium sulphate fractionation of a liver extract, and the final preparation is almost free of cholinesterase activity. The enzyme is TEPP- and eserine-insensitive. The possible role of this enzyme in recovery of muscular control after succinyldicholine administration is discussed.