Peptidoglycan Composition of Vancomycin-ResistantEnterococcus faecium
- 1 January 1996
- journal article
- research article
- Published by Mary Ann Liebert Inc in Microbial Drug Resistance
- Vol. 2 (2) , 225-229
- https://doi.org/10.1089/mdr.1996.2.225
Abstract
Muropeptide composition of peptidoglycan isolated from isogenic vancomycin-resistant and -sensitive Enterococcus faecium strains was analyzed by reverse-phase high-performance liquid chromatography combined with amino acid and fast atom bombardment mass spectrometric analyses. Peptidoglycan of the sensitive and resistant strains was the same and was composed of tri- and tetrapeptides stem peptide subunits with or without aspartate or asparagine substitutions on the ε-amino group of the lysine residue. Thus, the synthesis of lactate-terminating peptidoglycan precursors in vancomycin-resistant E. faecium did not affect the chemical composition of peptidoglycan.Keywords
This publication has 22 references indexed in Scilit:
- Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United StatesAntimicrobial Agents and Chemotherapy, 1995
- Genetics and mechanisms of glycopeptide resistance in enterococciAntimicrobial Agents and Chemotherapy, 1993
- Modified peptidoglycan precursors produced by glycopeptide-resistant enterococciFEMS Microbiology Letters, 1992
- Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureusFEMS Microbiology Letters, 1992
- Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanABiochemistry, 1991
- Plasmid-Mediated Resistance to Vancomycin and Teicoplanin in Enterococcus FaeciumNew England Journal of Medicine, 1988
- Enterococcus hirae, a New Species That Includes Amino Acid Assay Strain NCDO 1258 and Strains Causing Growth Depression in Young ChickensInternational Journal of Systematic and Evolutionary Microbiology, 1985
- Structure of vancomycin and its complex with acetyl-D-alanyl-D-alanineNature, 1978
- Sequential addition of glycine from glycyl-tRNA to the lipid-linked precursors of cell wall peptidoglycan in Staphylococcus aureusBiochemical and Biophysical Research Communications, 1969
- The Peptide Nα-(L-Alanyl-D-isoglutaminyl)- Nε-(D-isoasparaginyl)-L-lysyl-D -alanine and the Disaccharide N-Acetylglucosaminyl-β-1,4-N-acetylmuramic Acid in Cell Wall Peptidoglycan of Streptococcus faecalis Strain ATCC 9790*Biochemistry, 1967