Effect of Feeding Insecticides

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Abstract
The hydrolysis of acetylcholine (cholinesterase activity) and malathion, diethyl succinate, or triacetin (carboxyesterase activity) by tissues of rats given single Injections or fed diets containing organophosphorus insecticides was measured. Dietary concentrations of dioxathion (Delnav), ronnel, and malathion, which were less than those required to inhibit red blood cell or brain cholinesterase activities, inhibited liver and plasma carboxyesterases. Red blood cell cholinesterase was equally as sensitive as liver and plasma carboxyesterase to Inhibition by low dietary concentrations of parathion, however. Rats that were fed concentrations of dioxathion or ronnel, which produced about 50% inhibition of liver carboxyesterase but not Inhibition of brain cholinesterase, were more susceptible to brain cholinesterase Inhibition following a single dose of 200 mg/kg of malathion. No potentiation of brain cholinesterase Inhibition was detected in ronnel-fed rats that were challenged with 15 mg/kg of 0-ethyl 0-p-nitrophenyl phenylphosphonothioate (EPN).