The Son of sevenless Gene Product: a Putative Activator of Ras
- 31 January 1992
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 255 (5044) , 603-606
- https://doi.org/10.1126/science.1736363
Abstract
The Son of sevenless (Sos) gene functions in signaling pathways initiated by the sevenless and epidermal growth factor receptor tyrosine kinases. The Sos gene has now been isolated and sequenced. Its product is a 1595-amino acid protein similar to the CDC25 protein in Saccharomyces cerevisiae, a guanine nucleotide exchange factor that activates Ras. These results imply a role for the ras pathway in Drosophila neuronal development.Keywords
This publication has 17 references indexed in Scilit:
- Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptorNature, 1991
- Functional cloning of BUD5, a CDC25-related gene from S. cerevisiae that can suppress a dominant-negative RAS2 mutantCell, 1991
- The role of cell-cell interaction in the development of the drosophila visual systemNeuron, 1990
- Control of photoreceptor cell fate by the sevenless protein requires a functional tyrosine kinase domainCell, 1988
- Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginal disc of DrosophilaCell, 1987
- Neuronal differentiation in the Drosophila ommatidiumDevelopmental Biology, 1987
- Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eyeCell, 1987
- The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathwayCell, 1987
- The drosophila ras oncogenes: Structure and nucleotide sequenceCell, 1984
- Genetic Transformation of Drosophila with Transposable Element VectorsScience, 1982