Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine-kinase receptor
- 1 July 1991
- journal article
- Published by Springer Nature in Nature
- Vol. 352 (6332) , 207-212
- https://doi.org/10.1038/352207a0
Abstract
During development of the Drosophila retina, the R8 photoreceptor neuron induces a neighbouring cell to assume an R7 cell fate. Genetic data suggest that the induction is mediated by two transmembrane proteins encoded by bride of sevenless and sevenless. A direct interaction between these two proteins was demonstrated by the heterotypic aggregation of cell lines expressing them. In the developing eye the sevenless-dependent internalization of bride of sevenless by the R7 precursor cell provides evidence for a direct interaction between these two proteins in vivo.Keywords
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