Studies of the Effect of X‐Rays on the β‐Glucuronidase Activity in the Gastric Mucous Membrane and in the Liver and of its Relation to the Glucuronide Conjugation

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Abstract
The effect of local X‐irradiation of the liver and the stomach on the β‐glucuronidase activity was studied in rats. In the liver it was found that with the both radiation doses, 400 r and 1,200 r, there was an initial increase in the enzyme activity which was after the first day followed by a return slightly though insignificantly below the control level. After the 3rd day a new rise greatly above the control level was present. This persisted at least 2 weeks after the irradiation.In the gastric mucosa there was only a depression in the enzyme activity beginning already 3 hours after the irradiation. The depression continued over a period of at least 12 days. Comparison of the post‐radiation, β‐glucuronidase activity and the glucuronide conjugation capacity of the same tissues revealed a parallelism for the gastric mucosa. In the liver the same stimulation and depression phases were also present for the both activities. Still they were not parallel so that the time relationships showed a distinct dissociation. The possible meaning of these relations are discussed.