Observations on Streptomyces Griseus. VI. Further Studies on Strain Selection for Improved Streptomycin Production
- 1 July 1953
- Vol. 45 (4) , 481-487
- https://doi.org/10.1080/00275514.1953.12024288
Abstract
SUMMARY Through the use of ultraviolet light, x-rays and natural selection, mutants were obtained that were capable of producing markedly higher streptomycin broth potencies than the starting culture. The highest streptomycin activities observed were over eight times more than the broth potencies produced by the starting culture, Waksman No. 4, under the same experimental conditions. Many thousands of cultures were examined in the selection of cultures described in this paper. The selectivity that often results from the experimental conditions used in screening cultures is emphasized.This publication has 4 references indexed in Scilit:
- Observations on Streptomyces Griseus. IV. Induced Mutation and Strain SelectionMycologia, 1949
- IMPROVEMENT IN STREPTOMYCIN-PRODUCING STRAINS OF STREPTOMYCES GRISEUS BY ULTRAVIOLET AND X-RAY ENERGYJournal of Bacteriology, 1949
- THE DEVELOPMENT OF IMPROVED PENICILLIN‐PRODUCING MOLDSAnnals of the New York Academy of Sciences, 1946
- PENICILLIN YIELDS FROM NEW MOLD STRAINSJournal of the American Chemical Society, 1946