Study of the Efficacy, Biodistribution, and Safety Profile of Therapeutic Gutless Adenovirus Vectors as a Prelude to a Phase I Clinical Trial for Glioblastoma
- 17 February 2010
- journal article
- Published by Wiley in Clinical Pharmacology & Therapeutics
- Vol. 88 (2) , 204-213
- https://doi.org/10.1038/clpt.2009.260
Abstract
Glioblastoma multiforme (GBM) is the most common and most aggressive primary brain tumor in humans. Systemic immunity against gene therapy vectors has been shown to hamper therapeutic efficacy; howev...Keywords
This publication has 45 references indexed in Scilit:
- Release of HMGB1 in Response to Proapoptotic Glioma Killing Strategies: Efficacy and NeurotoxicityClinical Cancer Research, 2009
- Biodistribution of an oncolytic adenovirus after intracranial injection in permissive animals: a comparative study of Syrian hamsters and cotton ratsCancer Gene Therapy, 2008
- High-Capacity Adenovirus Vector-Mediated Anti-Glioma Gene Therapy in the Presence of Systemic Antiadenovirus ImmunityJournal of Virology, 2008
- One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical ImplicationsMolecular Therapy, 2007
- Intracranial glioblastoma models in preclinical neuro-oncology: neuropathological characterization and tumor progressionJournal of Neuro-Oncology, 2007
- Sustained phenotypic correction in a mouse model of hypoalphalipoproteinemia with a helper-dependent adenovirus vectorGene Therapy, 2006
- Effective High-Capacity Gutless Adenoviral Vectors Mediate Transgene Expression in Human Glioma CellsMolecular Therapy, 2006
- In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brainThe Journal of Experimental Medicine, 2006
- Quantification of High-Capacity Helper-Dependent Adenoviral Vector Genomes In Vitro and In Vivo, Using Quantitative TaqMan Real-Time Polymerase Chain ReactionHuman Gene Therapy, 2006
- Radiotherapy plus Concomitant and Adjuvant Temozolomide for GlioblastomaNew England Journal of Medicine, 2005