One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical Implications
Open Access
- 1 December 2007
- journal article
- Published by Elsevier in Molecular Therapy
- Vol. 15 (12) , 2154-2163
- https://doi.org/10.1038/sj.mt.6300305
Abstract
No abstract availableKeywords
This publication has 55 references indexed in Scilit:
- Immunological thresholds in neurological gene therapy: highly efficient elimination of transduced cells might be related to the specific formation of immunological synapses between T cells and virus-infected brain cellsNeuron Glia Biology, 2006
- Immune Regulation of Transgene Expression in the Brain: B Cells Regulate an Early Phase of Elimination of Transgene Expression from Adenoviral VectorsViral Immunology, 2006
- In vivo mature immunological synapses forming SMACs mediate clearance of virally infected astrocytes from the brainThe Journal of Experimental Medicine, 2006
- Rapid Upregulation of Interferon-Regulated and Chemokine mRNAs upon Injection of 108International Units, but Not Lower Doses, of Adenoviral Vectors into the BrainJournal of Virology, 2006
- Regulatable Gutless Adenovirus Vectors Sustain Inducible Transgene Expression in the Brain in the Presence of an Immune Response against AdenovirusesJournal of Virology, 2006
- Neuronal expression of the transcription factor Gli1 using the Tα1 α-tubulin promoter is neuroprotective in an experimental model of Parkinson's diseaseGene Therapy, 2004
- Preexisting Antiadenoviral Immunity Is Not a Barrier to Efficient and Stable Transduction of the Brain, Mediated by Novel High-Capacity Adenovirus VectorsHuman Gene Therapy, 2001
- Acute Direct Adenoviral Vector Cytotoxicity and Chronic, but Not Acute, Inflammatory Responses Correlate with Decreased Vector-Mediated Transgene Expression in the BrainMolecular Therapy, 2001
- Use of helper-dependent adenoviral vectors of alternative serotypes permits repeat vector administrationGene Therapy, 1999
- Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparationsJournal of Comparative Neurology, 1999